[COVID-19 associated pneumonia despite repeatedly negative PCR-analysis from oropharyngeal swabs]. / COVID-19-assoziierte Pneumonie trotz persistierend negativen PCR-Tests aus oropharyngealen Abstrichen.

PATIENT HISTORY AND CLINICAL FINDINGS: A 46-year old construction worker presented at the emergency department with two orthostatic syncopes. The patient complained of prolonged fever and coughs for 7 days which had not improved after oral treatment with sultamicillin for 5 days, prescribed by the patient's general practitioner. Physical examination showed high blood pressure due to previously known hypertension. Other vital signs without pathological findings. Pulmonary auscultation showed basal soft crackling noises of the left lung. FINDINGS AND DIAGNOSIS: Laboratory examination showed increased values for LDH, pro-BNP and CRP and normal values for leucocytes and procalcitonin. Conventional X-Ray of the chest showed bipulmonal lateral atypical infiltrates. After the first PCR turned in negative another PCR-analysis for SARS-CoV-2 of a deep oral swab-sample was performed since the clinical, laboratory and radiological findings were typical for COVID-19. Again, SARS-CoV-2-RNA was not detected. A CT-scan of the chest showed bipulmonal lateral ground-glass attenuation, again typical for COVID-19 associated pneumonia. After a third attempt for a PCR-analysis of a deep oral swab-sample was negative, analysis of a sputum was performed which finally confirmed the diagnosis of COVID-19 associated pneumonia. THERAPY AND COURSE OF EVENTS: The patient was admitted for evaluation of syncopes and suspect of COVID-19 associated pneumonia. The patient was prophylactically isolated while the result of SARS-CoV-2-PCR from a deep oral swab was pending. Suspecting a possible secondary bacterial infection at the beginning, intravenous antibiotic treatment with ampicillin/sulbactam was initiated. While further examinations showed no indication for bacterial infection, antibiotics were discontinued after 3 days. Due to clinical recovery antiviral therapy was not performed after confirming the diagnosis. The patient was discharged 17 days after onset of first symptoms without any requirements for further isolation. CONCLUSION: This casuistic describes a case of COVID-19 associated pneumonia presenting with typical clinical features, laboratory and radiological findings. Detection of viral RNA was not successful from deep oral swab-samples despite repeated attempts. Finally, PCR-analysis of sputum confirmed the diagnosis. Analysis of deeper airway samples (sputum, bronchoalveolar lavage, tracheal secretions) or stool for SARS-CoV-2 should be performed in cases of evident clinical suspicion of COVID-19 and negative PCR results from deep oral swabs.

Coronaviruserkrankung 2019 (COVID-19) und Schwangerschaft

Seit Beginn der Coronaviruspandemie mit SARS-CoV‑2 („severe acute respiratory syndrome coronavirus 2“) im Januar 2020 wurden bereits mehr als 100 Fälle von chinesischen Schwangeren publiziert, darunter auch Fälle mit Gestationsdiabetes (GDM). In vorliegender Übersicht wird über die Klinik von COVID-19 sowie geburtshilfliche und neonatale Ergebnisdaten berichtet. Leitsymptome der insgesamt milder verlaufenden Infektion sind Fieber, Husten und Atembeschwerden. Es gibt bislang keine Beweise für eine intrauterine Transmission des Virus und auch keinen Beleg für einen Transfer in bzw. durch Muttermilch. Postnatale Infektionen von Säuglingen infizierter Mütter sind belegt, die Verläufe mild. Die vorliegenden Daten sind geeignet, Angehörige der Gesundheitsberufe auf die zu erwartenden Infektionen schwangerer Frauen mit der Komorbidität Diabetes mellitus vorzubereiten.